However, patients with severe renal impairment may require a lower initial dose, with subsequent adjustments at smaller increments and at longer intervals than in patients without renal impairment (see section 5.2). No dose adjustment is recommended, but caution is advised when treating patients with renal impairment. The influence of renal impairment on the pharmacokinetics of haloperidol has not been evaluated. The combined total dose of haloperidol from both formulations must not exceed the corresponding maximum oral haloperidol dose of 5 mg/day or the previously administered oral haloperidol dose in patients who have received long-term treatment with oral haloperidol.Doses above 75 mg every 4 weeks should only be considered in patients who have tolerated higher doses and after reassessment of the patient's individual benefit-risk profile.The most effective dose is expected to range between 25 and 75 mg.It is recommended only to adjust the haloperidol decanoate dose if required (based on individual patient response) until an optimal therapeutic effect is obtained.A low haloperidol decanoate dose of 12.5 to 25 mg is recommended.Table 2: Haloperidol decanoate dose recommendations for elderly patients The combined total dose of haloperidol from both formulations must not exceed the corresponding maximum oral haloperidol dose of 20 mg/day.Supplementation with non-decanoate haloperidol may be considered during transition to HALDOL Decanoate, dose adjustment or episodes of exacerbation of psychotic symptoms (based on individual patient response).Supplementation with non-decanoate haloperidol Adjustment of the dosing interval may be required (based on individual patient response).A maximum dose of 300 mg every 4 weeks must not be exceeded because the safety concerns outweigh the clinical benefits of treatment.It is recommended to assess the individual benefit-risk when considering doses above 200 mg every 4 weeks.The most effective dose is expected to range between 50 and 200 mg.It is recommended to adjust the haloperidol decanoate dose by up to 50 mg every 4 weeks (based on individual patient response) until an optimal therapeutic effect is obtained.Based on this conversion, the haloperidol decanoate dose will be 25 to150 mg for most patients.A haloperidol decanoate dose of 10 to 15 times the previous daily dose of oral haloperidol is recommended.Date of first authorisation/renewal of the authorisation 6.6 Special precautions for disposal and other handling.4.7 Effects on ability to drive and use machines.4.5 Interaction with other medicinal products and other forms of interaction.4.4 Special warnings and precautions for use.4.2 Posology and method of administration.Show table of contents Hide table of contents

Haloperidol antidote